aloe vera leaf gel in treatment of advanced type 2 diabetes mellitus needing insulin therapy: a randomized double-blind placebo-controlled clinical trial

background: advanced type 2 diabetes mellitus (t2dm) needing insulin therapy is a common disease. previous studies indicate that aloe (aloe vera l.) leaf gel may positively affect the blood glucose and lipid levels in patients with advanced t2dm needing insulin.  objective: evaluation of the efficacy and safety of aloe leaf gel in the treatment of type 2 diabetic patients resistant to oral synthetic anti-hyperglycemic drugs needing insulin.  methods: in this randomized double - blind placebo-controlled clinical trial with the patients aged 40-60 years, the efficacy and safety of taking aloe leaf gel (one 300 mg capsule every 12 hours for 2 months) combined with oral synthetic anti-hyperglycemic drugs in treatment of 35 patients were evaluated and compared with the placebo group (n = 35).  results: the aloe leaf gel lowered the blood levels of fasting glucose and glycosylated hemoglobin significantly (p = 0.041 and p = 0.023 respectively) without any significant effects on the lipid profile and liver/kidney function tests (p > 0.05) compared with placebo at the endpoint. no adverse effects were reported.  conclusion: the results suggest that aloe leaf gel may safely improve glycemic control in patients with advanced t2dm needing insulin.